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The 17-year-old girl, from Enfield in Hartford County who was not identified, died just after the 2 p.m. wreck on North Blandford Road in the town of Blandford, the Hampden District Attorney's Office said.
Blandford is about 45 minutes west of Springfield.
Authorities have not released details about what led to the crash or how many vehicles were involved. No other fatalities were reported.
Blandford firefighters and police closed North Blandford Road for several hours Sunday as they cleaned and cleared the scene.
Massachusetts State Police are investigating the wreck. More details will be released later.
Correction: A previous version of this story incorrectly spelled Blandford.
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